25. Pharmacokinetics/Pharmacodynamics Expert Meeting
From April 20 till April 22, 2023
Event location: Landgut Stober (Link)
Presentations and associated discussions will focus on the following topics:
- DDI — What is new 2023?
- Translation to & from patients — Concepts to address the translational challenge
- Drug development for brain diseases — New Approaches
We look forward to seeing you at the Landgut Stober near Berlin in April 2023.
Kind regards, Corina Becker & Joachim Höchel on behalf of the Organizing Committee
The programme of the 25. Pharmacokinetics/Pharmacodynamics Expert Meeting
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Meeting Location: |
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| Landgut Stober, Behnitzer Dorfstraße 27-31, 14641 Nauen, OT Groß Behnitz (Link) | |||
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| 17:00-19:00 | Arrival Landgut Stober |
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| 19:00 | Dinner | ||
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| 08:30 | Welcome Corina Becker & Joachim Höchel on behalf of the Organizing Committee |
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Session 1: |
Drug-drug interactions– What’s new in 2023? |
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| 08:40 | ICH M12 / EMA / FDA – new guidelines & resulting implications (Download Slides) Sheila Peters, Boehringer Ingelheim, Germany |
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| 09:10 | Discussion | ||
| 09:25 | PBPK Modeling of drug-drug interactions – techniques & regulatory acceptance Stephan Schaller, esqLABS, Germany |
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| 09:55 | Discussion | ||
| 10:10 | Coffee Break | ||
| 10:45 |
Replacement of rifampicin as strong CYP3A inducer – the industry experience (Download Slides) Thomas Gießman, Boehringer Ingelheim, Germany Learnings from Carbamazepine DDI Studies (Download Slides) Tommaso Fadini, Bayer AG, Germany |
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| 11:15 | Discussion | ||
| 11:30 | Drug-drug interactions with therapeutic proteins and peptides (Download Slides) Antoine Deslandes, Sanofi, France |
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| 12:00 | Discussion | ||
| 12:15 | Master / PhD students: Best presentation award (5 min presentation followed by 5 min discussion each) |
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| 13:00 | Joint Lunch | ||
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Session 2: |
Translation to and from patients – Current concepts to address the challenge Session Chairs: Alexander Staab & Corina Becker |
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| 14:00 | Translation 4 Patients – The translational sciences framework at Boehringer Ingelheim Jens Borghardt, Valerie Nock, Boehringer Ingelheim, Germany |
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| 14:30 | Discussion | ||
| 14:45 | Project Optimus: Implications for drug development Jeffrey Stuart, MSD, United States (remote) |
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| 15:15 | Discussion | ||
| 15:30 | Finding the needle in the haystack in oncology Phase I trials - what's next in translational PKPD? (Download Slides) Antje Walz, 3T Biosciences, Switzerland |
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| 15:45 | Discussion | ||
| 15:55 | ICH Guideline Development on Model-Informed Drug Development - Update from the M15 Expert Working Group (Download Slides) Jörg Lippert, EFPIA Deputy Topic Lead |
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| 16:15 | Coffee Break | ||
| 16:40 | Hans Günter Schäfer Award Moderated by Joachim Höchel |
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| 17:10 | 25 PK/PD Expertentreffen – ein persönlicher Rückblick Wolfgang Mück, formerly Bayer AG, Germany (Presentation will be held in German) |
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| 17:30 | End of Session | ||
| 18:00 | Joint Jogging | ||
| 19:30 | Dinner | ||
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Session 3: |
Drug development for brain diseases – New approaches |
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| 09:00 | Central nervous system PK/PD research – status quo: Challenges and opportunities (Download Slides) Elizabeth de Lange, Leiden Amsterdam Centre for Drug Research (LACDR), The Netherlands |
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| 09:20 | Discussion | ||
| 09:30 | The Leiden CNS PBPK (LeiCNSPK) models to predict CNS drug distribution, integrating all PK processes involved (Download Slides) Elizabeth de Lange, Leiden Amsterdam Centre for Drug Research (LACDR), The Netherlands |
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| 09:50 | Discussion | ||
| 10:00 | Coffee Break | ||
| 10:30 | Advanced modalities to treat neurodegenerative disease: Cell-based therapy for Parkinson’s disease (Download Slides) Stefan Irion, BlueRock Therapeutics, USA |
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| 11:00 | Discussion | ||
| 11:15 | New conceptual approaches for mental diseases: precision psychiatry (Download Slides) Joachim Scholpp, Boehringer Ingelheim, Germany |
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| 11:45 | Discussion | ||
| 12:00 | Closing Remarks Corina Becker & Joachim Höchel on behalf of the Organizing Committee |
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| 12:05 | Joint Lunch | ||
| 13:00 | End of Meeting | ||
