20th AGAH Annual Meeting
20 Years of Applied Human Pharmacology in Clinical Drug Development –
Lessons Learned and Translation to Future Needs
21 – 23 February 2010, Hamburg, Germany
To foster the creation of an association for applied human pharmacology, a group of human pharmacology experts working in Phase 1 Units in Industry and CROs organised a first conference in 1990 to exchange information and experience on how to perform human pharmacology trials according to the then newly established GCP principles and to enable faster drug development. This led to the foundation of AGAH (Association For Applied Human Pharmacology) which became incorporated in 1991, creating a lot of enthusiasm resulting every year in an interesting programme for the annual meetings. Thus, 2010 has marked the 20th AGAH Annual Meeting.
This was an excellent opportunity to critically review the progress made since, the lessons learned, as well as the potential to translate this knowledge into strategies and tools to successfully manage the forthcoming challenges in human pharmacology: drugs with new mechanisms of action, personalised therapies, higher pressure to achieve better predictability of a molecule’s suitability for further development, shorter development times and globalization of trial performance.
This conference gave the opportunity to critically review current and past approaches to drug development, learn about experiences and practical aspects of human pharmacology, discuss strategies and up-to-date tools for further improvement of clinical development in special populations, difficult pharmacokinetic conditions and an ever-changing regulatory environment.